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Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

Course General Introduction Information

Course Code:

PHA328

Course Name:

Clinical Biochemistry

Course Semester:

Spring

Course Credits:

ECTS

Language of instruction:

Course Requirement:

Does the Course Require Work Experience?:

Type of course:

Necessary

Course Level:

Bachelor

TR-NQF-HE:6. Master`s Degree

QF-EHEA:First Cycle

EQF-LLL:6. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Dr.Öğr.Üyesi ASİYE YURTTAŞ

Course Lecturer(s):

ASİYE YURTTAŞ

Course Assistants:

Course Purpose and Content

Course Objectives:

The aim of this course is to explain the metabolism of biochemical molecules and to reveal the relationship of the parameters in metabolism with diseases and clinics, as well as to teach the differential diagnosis of diseases and the qualitative and quantitative determination of biochemical parameters. This course include Importance of clinical biochemistry, Water sodium and potassium balance, Globular and fibrous proteins and their relations with diseases, Types of hemoglobin structure and anemia, Carbohydrate metabolism disorders, Lipid metabolism disorders, Cardiovascular diseases, Plasma proteins, Enzyme activities and their importance in diseases, Liver function and disorders, the topics of calcium phosphate and magnesium balance.

Course Content:

1. To be able to associate the causes of diseases with clinical diagnosis. 2. Evaluate clinical analysis reports. 3. To be able to give information about the biochemical mechanism of drugs used in patients and to be able to guide patients.
4. Examine the relationship between the functions of biomolecules and metabolic disorders
5. Identify risk factors for diseases related to metabolic disorders
6. understand the relationship between the formation of diseases and the metabolism of biochemical molecules
7. To be able to learn differential diagnosis of diseases and determination of biochemical parameters related to diseases
8. To be able to learn how biochemical parameters affect diseases

Learning Outcomes

The students who have succeeded in this course;
1) To be able to associate the causes of diseases with clinical diagnosis.
2) Clinical analysis reports should be able to evaluate
3) To be able to give information about the biochemical mechanism of drugs used in patients and to be able to direct patients.
4) Examine the relationship between the functions of biomolecules and metabolic disorders
5) Examine the relationship between the functions of biomolecules and metabolic disorders
6) Understand the relationship between the formation of diseases and metabolism of biochemical molecules
7) To be able to learn differential diagnosis of diseases and determination of biochemical parameters related to diseases
8) To be able to learn how biochemical parameters affect diseases

Course Flow Plan

Week	Subject	Related Preparation
1)	1. The importance of clinical biochemistry	1. Principles of Biochemistry, Lehninger, Third edition, 2. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993
2)	2. Water, sodium and potassium balance	1. Clinical Chemistry, Sixth edition, William J. Marshall, Stephen K Bangert, Mosby Elsevier Publishing, 2008 2. Principles of Biochemistry, Lehninger, Third edition, 3. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993
3)	Globular and fibrous proteins and their relationship with diseases	1. Clinical Chemistry, Sixth edition, William J. Marshall, Stephen K Bangert, Mosby Elsevier Publishing, 2008 2. Principles of Biochemistry, Lehninger, Third edition, 3. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993
4)	Carbohydrate metabolism and disorders	1. Clinical Chemistry, Sixth edition, William J. Marshall, Stephen K Bangert, Mosby Elsevier Publishing, 2008 2. Principles of Biochemistry, Lehninger, Third edition, 3. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993
5)	Lipid metabolism disorders I	1. Clinical Chemistry, Sixth edition, William J. Marshall, Stephen K Bangert, Mosby Elsevier Publishing, 2008 2. Principles of Biochemistry, Lehninger, Third edition, 3. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993
6)	Lipid metabolism disorders II	1. Clinical Chemistry, Sixth edition, William J. Marshall, Stephen K Bangert, Mosby Elsevier Publishing, 2008 2. Principles of Biochemistry, Lehninger, Third edition, 3. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993
7)	Plasma proteins	1. Clinical Chemistry, Sixth edition, William J. Marshall, Stephen K Bangert, Mosby Elsevier Publishing, 2008 2. Principles of Biochemistry, Lehninger, Third edition, 3. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993
8)	MIDTERM EXAM
9)	Cardiovascular diseases	1. Clinical Chemistry, Sixth edition, William J. Marshall, Stephen K Bangert, Mosby Elsevier Publishing, 2008 2. Principles of Biochemistry, Lehninger, Third edition, 3. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993
10)	Blood gases	1. Clinical Chemistry, Sixth edition, William J. Marshall, Stephen K Bangert, Mosby Elsevier Publishing, 2008 2. Principles of Biochemistry, Lehninger, Third edition, 3. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993
11)	Enzymes and their importance in clinical diagnosis	1. Clinical Chemistry, Sixth edition, William J. Marshall, Stephen K Bangert, Mosby Elsevier Publishing, 2008 2. Principles of Biochemistry, Lehninger, Third edition, 3. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993
12)	Enzymes and their importance in clinical diagnosis II	1. Clinical Chemistry, Sixth edition, William J. Marshall, Stephen K Bangert, Mosby Elsevier Publishing, 2008 2. Principles of Biochemistry, Lehninger, Third edition, 3. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993
13)	Liver function and disorders	1. Clinical Chemistry, Sixth edition, William J. Marshall, Stephen K Bangert, Mosby Elsevier Publishing, 2008 2. Principles of Biochemistry, Lehninger, Third edition, 3. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993
14)	Liver function and disorders II	1. Clinical Chemistry, Sixth edition, William J. Marshall, Stephen K Bangert, Mosby Elsevier Publishing, 2008 2. Principles of Biochemistry, Lehninger, Third edition, 3. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993
15)	FINAL

Sources

Course Notes / Textbooks:
References:	1. Clinical Chemistry, Sixth edition, William J. Marshall, Stephen K Bangert, Mosby Elsevier Publishing, 2008 2. Principles of Biochemistry, Lehninger, Third edition, 3. Harper’ın Biyokimyası. R.K.Murray,P.A.Mayes,D.K.Granner,V.W.Rodwell, ed: G.Menteş, B.Ersöz, Sistem Yayıncılık Mat,22, 1993

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Medium	3 Highest

Program Outcomes

Level of Contribution

Learning Activity and Teaching Methods

Measurement and Evaluation Methods and Criteria

Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama)
Sözlü sınav
Sunum
Staj/ Yerinde Uygulama Değerlendirmesi

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
total		%
PERCENTAGE OF SEMESTER WORK		% 0
PERCENTAGE OF FINAL WORK		%
total		%

İş Yükü ve AKTS Kredisi Hesaplaması

Activities	Number of Activities	Aktiviteye Hazırlık	Aktivitede Harçanan Süre	Aktivite Gereksinimi İçin Süre	Workload
Course Hours	14	3			42
Midterms	1	1			1
Final	1	1			1
Total Workload					44