Molecular Biology and Genetics Preview
Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

Course General Introduction Information

Course Code:

MBG304

Course Name:

Cancer Biology

Course Semester:

Spring

Course Credits:

ECTS

Language of instruction:

Course Requirement:

Does the Course Require Work Experience?:

Type of course:

Necessary

Course Level:

Bachelor

TR-NQF-HE:6. Master`s Degree

QF-EHEA:First Cycle

EQF-LLL:6. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

MERVE ERKISA GENEL

Course Lecturer(s):

Asst. Prof. MERVEE RKISA GENEL

Course Assistants:

Course Purpose and Content

Course Objectives:

The aim of this course for every student is to learn cancer cell structure and pathology at the molecular and genetic level.

Course Content:

1. Introduction to Cancer Biology
2. Cell cycle
3. Consept of Cancer Stem Cell
4. Metastasis, Angiogenesis and EMT
5. Presentation of the article "The Hallmarks of cancer"
6. Scientific reserach article presentation
7. MIDTERM EXAM
8. Cell death
9. Cancer metabolism
10. Cancer epigenetics
11. Cancer microenvironment and immunology
12. Personalized treatment and discovery of anti-cancer drugs in cancer research
13. Discovery of biomarkers for cancer diagnosis and treatment
14. FINAL

Learning Outcomes

The students who have succeeded in this course;
1) 1. To be able to define the basic concepts of Cancer Biology and to obtain objective information about the relevant field within the scope of the program.
2) To have knowledge about the molecular mechanisms of the cell cycle of cancer and to learn the process of carcinogenesis at the molecular level.
3) Learning the concept of cancer stem cells and their place in cancer diagnosis and treatment
4) Must know the stages of metastasis and understand its difficulties in the treatment process.
5) Must be able to understand the specific characteristics of cancer from past to present through article presentations.
6) Must be able to comprehend the specific newly added features of cancer from past to present through article presentations.
7) MIDTERM EXAM
8) Must be able to understand the resistance mechanisms of cancer cells to cell death
9) Must be able to understand that cancer cells reprogram their metabolism through different mechanisms.
10) Must be able to understand that cancer should be considered not only as a genetic disease but also as an epigenetic disease.
11) Must be able to think of the cancer cell in 3 dimensions rather than 2 dimensions and understand the role of the tumor microenvironment in cancer biology.
12) Must be able to understand the importance of personalized medicine in cancer treatment. Know the stages of anti-cancer drug design, development and discovery and understand its importance.
13) Must be able to understand the widespread use and importance of molecular biology techniques in the diagnosis and treatment of cancer.
14) FINAL EXAM

Course Flow Plan

Week	Subject	Related Preparation
1)	Introduction to Cancer Biology	PRESENTATION
2)	Cell cycle	PRESENTATION
3)	CANCER STEM CELL	PRESENTATION
4)	Metastasis, Angiogenesis and EMT	PRESENTATION
5)	Presentation of the article "The Hallmarks of cancer"	RESEARCH ARTICLE PRESENTATION
6)	Presentation of the article "The Hallmarks of cancer"-2	SCIENTIFIC RESEARCH ARTICLE PRESENTATION
7)	MIDTERM	MIDTERM
8)	CELL DEATH MECHANISM	PRESENTATION
9)	CANCER METABOLISM	PRESENTATION
10)	CANCER EPIGENETICS	PRESENTATION
11)	CANCER MICROENVIRONMENT	PRESENTATION
12)	Personalized treatment and anti-cancer drug development in cancer research	PRESENTATION
13)	Discovery of biomarkers for cancer diagnosis and treatment	PRESENTATION
14)	FINAL	FINAL

Sources

Course Notes / Textbooks:	1. Prof. Dr. Yusuf Baran, Kanser Moleküler Biyolojisi, Hipokrat Tıp Kitabevi, 2. Baskı 2023. 2. The Biology of Cancer, Robert A. Weinberg 3. Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics, Lauren Pecorino
References:	1. Prof. Dr. Yusuf Baran, Kanser Moleküler Biyolojisi, Hipokrat Tıp Kitabevi, 2. Baskı 2023. 2. The Biology of Cancer, Robert A. Weinberg 3. Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics, Lauren Pecorino

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Medium	3 Highest

	Program Outcomes	Level of Contribution
1)	Having knowledge and understanding of Molecular Biology and Genetics subjects, established on competencies gained in previous education and supported by using course books containing latest information, application tools and other scientific literature.
2)	Students can integrate knowledge and skills from molecular biology and genetics courses and can acquire further knowledge according to their own interests.
3)	Students acquire practical skills in fundamental molecular biology and genetics techniques.
4)	Ability of proposing solutions in unexpected, complicated situations on applications of Molecular Biology and Genetics by claiming responsibility individually or as a part of a team.
5)	Competency in planning academic studies on Molecular Biology and Genetics and carrying out these studies individually or collectively.
6)	Students can develop ability to analyse and interpret experimental data obtained in a laboratory setting statistically.
7)	Sufficient foreign language knowledge for communication between colleagues and following literature on Molecular Biology and Genetics.
8)	Students can use computational technologies to analyse scientific data and for information retrieval.
9)	Being aware of the necessity of lifelong education, reaching information, following the advances in science and technology and constant struggle of renewing oneself.
10)	Evaluating natural and social events with an environmental point of view and ability of informing and leading the public opinion
11)	Students acquire professional knowledge and skills to fulfil requirements of their future employers.
12)	Having proper social, ethical and scientific values and the will to protect these values on studies about collection, evaluation, contemplation, publication and application of data regarding Molecular Biology and Genetics.
13)	Students can understand and evaluate advantages and limitations of technological platforms in life sciences including genomics, genetic engineering and biotechnology.
14)	Students would have consciousness on subjects such as the quality management, worker welfare and safety.

Learning Activity and Teaching Methods

Anlatım
Beyin fırtınası /Altı şapka
Bireysel çalışma ve ödevi
Grup çalışması ve ödevi
Okuma
Homework
Problem Çözme
Rol oynama
Seminar
Soru cevap/ Tartışma

Measurement and Evaluation Methods and Criteria

Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama)
Bireysel Proje
Grup Projesi
Sunum
Bilgisayar Destekli Sunum
Örnek olay sunma

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Presentation	6	% 20
Midterms	1	% 30
Final	1	% 50
total		% 100
PERCENTAGE OF SEMESTER WORK		% 50
PERCENTAGE OF FINAL WORK		% 50
total		% 100

İş Yükü ve AKTS Kredisi Hesaplaması

Activities	Number of Activities	Aktiviteye Hazırlık	Aktivitede Harçanan Süre	Aktivite Gereksinimi İçin Süre	Workload
Course Hours	14	3			42
Presentations / Seminar	14	4			56
Homework Assignments	14	4			56
Midterms	1	1			1
Final	1	1			1
Total Workload					156