Istanbul Health and Technology University INFORMATION PACKAGE / COURSE CATALOGUE
| Pharmacy | |||||
| Bachelor | TR-NQF-HE: Level 6 | QF-EHEA: First Cycle | EQF-LLL: Level 6 | ||
Course General Introduction Information
| Course Code: | ECZ417 | ||||
| Course Name: | Pharmaceutical Toxicology I | ||||
| Course Semester: | Fall | ||||
| Course Credits: |
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| Language of instruction: | TR-EN | ||||
| Course Requirement: | |||||
| Does the Course Require Work Experience?: | No | ||||
| Type of course: | Necessary | ||||
| Course Level: |
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| Mode of Delivery: | Face to face | ||||
| Course Coordinator : | Prof. Dr. BÜKET ALPERTUNGA | ||||
| Course Lecturer(s): |
Prof. Dr. BÜKET ALPERTUNGA |
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| Course Assistants: |
Course Purpose and Content
| Course Objectives: | The aim of this course is to provide students with knowledge in the basic concepts of toxicology; dose-response relationships; factors affecting toxicity; toxicokinetic properties of xenobiotics; mechanism of toxic effects; chemical mutagenesis; chemical carcinogenesis; developmental toxicity and risk assessment in toxicology. |
| Course Content: | Basic principles of toxicology; toxicokinetic;. toxicological risk assessment; mechanisms of toxicity; chemical carcinogenesis and mutagenesis; developmental and reproductive toxicity. |
Learning Outcomes
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The students who have succeeded in this course;
1) To be able to explain the basic principles of toxicology. 2) To be able to interpret the dose-effect relationship of xenobiotics. 3) Should be able to know the characteristics of exposure to xenobiotics. 4) Should be able to know the principles of toxicity studies. 5) To be able to perform toxicological risk assessment of chemicals and safety assessment of consumer products. 6) To be able to comment on the biotransformations of xenobiotics. 7) To be able to comment on distribution and excretion of xenobiotics. 8) To be able to understand the factors which affects and modulate toxicity. 9) To be able to understand the mechanisms of toxicity. 10) To be able to know the mechanisms of cellular damage. 11) Should be knowledgeable enough to evaluate the mechanisms of action of chemical carcinogens. 12) Should have sufficient knowledge about the mechanisms that induce chemical mutagenesis. 13) Should have sufficient knowledge about developmental and reproductive toxicity. |
Course Flow Plan
| Week | Subject | Related Preparation |
| 1) | History and scope of toxicology | -- |
| 2) | Basic principles of toxicology | -- |
| 3) | Characteristics of exposure | -- |
| 4) | Absorption of toxicants | -- |
| 5) | Distribution and excretion of toxicants | -- |
| 6) | Biotransformation of xenobiotics- Phase I reactions | -- |
| 7) | Biotransformation of xenobiotics- Phase II reactions | -- |
| 8) | Mechanisms of toxicity | -- |
| 9) | Factors affecting toxicity | -- |
| 10) | Chemical carcinogenesis | -- |
| 11) | Chemical mutagenesis | -- |
| 12) | Developmental and reproductive toxicity | -- |
| 13) | Toxicity studies | -- |
| 14) | Toxicological risk assessment | -- |
Sources
| Course Notes / Textbooks: | 1. Poisoning and Drug Overdose, Olson KR, , 7th Edition, Lange Medical Books/McGraw-Hill, 2018. 2. Casarett and Doull’s Essentials of Toxicology, Claassen, C.D., Watkins J. B., , Lange Medical Books/McGraw-Hill, 2021. 3. Clinical Management of Poisoning and Drug Overdose, Haddad LM, Winchester JF, Saunders Company, Philadelphia, 2007. 4. Lu’s Basic Toxicology, Lu FC, Kacew S, Informa Healthcare, 2009. |
| References: | 1. Toksikoloji (2020), Nursen Başaran, Terken Baydar, Ülkü Ündeger Bucurgat, Sevtap Aydın Dilsiz, Pınar Erkekoğlu, Gözde Girgin, Belma Koçer Gümüşel, Aylin Gürbay, Hilal ÖzgÜneş, Suna Sabuncuoğlu, Gönül Şahin 2. Farmasotik Toksikoloji (2013), Gerard J. Mulder, Lennart Dencker, Nobel Yayinevi 3. Toksikolojinin Temelleri, Casarett and Doull’s (2017), Ankara Nobel Tip Kitabevi 4. Lu’s Basic Toxicology, Lu FC, Kacew S, Informa Healthcare, 2009. |
Course - Learning Outcome Relationship
| No Effect | 1 Lowest | 2 Medium | 3 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Access, evaluate and apply up-to-date scientific knowledge in the field of pharmacy | 5 |
| 2) | It conveys information to patients, health personnel and society on all matters related to drugs. | 4 |
| 3) | Has the necessary knowledge about the therapeutic effects, drug forms, pharmacokinetic properties, stability and incompatibilities of drug active substances and can use this information. | 3 |
| 4) | Recognizes, controls and standardizes quality assurance issues and processes of all pharmaceutical-related products. | 4 |
| 5) | Has knowledge and equipment about the administration and use of the drug to the patient, advises on rational and safe drug use, and supports pharmacovigilance practices. | 5 |
| 6) | Has knowledge about the production and production technologies of natural and synthetic pharmaceutical raw materials. | 3 |
| 7) | Have knowledge about the concepts related to the functioning, maintenance and pathology of biological systems that form the basis of human health. | 5 |
| 8) | Has sufficient knowledge and application skills on research, development and production of pharmaceutical and cosmetic products. | 3 |
| 9) | Plans and implements all subjects within the scope of pharmacy services in the hospital. | 3 |
| 10) | Has knowledge about licensing conditions, data protection, patent and pharmacoeconomics in pharmaceuticals. | 3 |
| 11) | She/He is administratively and technically equipped in every field where the pharmacy profession is responsible by law, and produces solutions to problems in line with scientific data / evidence. | 4 |
| 12) | Combines basic and applied sciences with pharmacy profession practices and uses them in the field of pharmacy. | 5 |
| 13) | Has sufficient knowledge and application skills on physical, chemical, biological and toxicological analyzes of pharmaceutical, biotechnological and radiopharmaceutical products. | 5 |
| 14) | Acts in accordance with ethical and legal principles in the field of pharmacy. | 5 |
| 15) | Has the necessary competencies to work with colleagues and other health professionals in terms of communicative, managerial and social skills. | 3 |
| 16) | Provides consultancy on medicinal plants, herbal supplements and food supplements. | 1 |
| 17) | Knows pharmaceutical care practices, understands and evaluates drug interactions. | 4 |
| 18) | Knows the risks associated with the use of drugs and other chemical substances and laboratory practice. | 5 |
Learning Activity and Teaching Methods
| Anlatım | |
| Course | |
| Grup çalışması ve ödevi | |
| Homework | |
| Soru cevap/ Tartışma |
Measurement and Evaluation Methods and Criteria
| Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama) | |
| Homework | |
| Sunum |
Assessment & Grading
| Semester Requirements | Number of Activities | Level of Contribution |
| Presentation | 1 | % 8 |
| Midterms | 1 | % 32 |
| Final | 1 | % 60 |
| total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 40 | |
| PERCENTAGE OF FINAL WORK | % 60 | |
| total | % 100 | |
İş Yükü ve AKTS Kredisi Hesaplaması
| Activities | Number of Activities | Aktiviteye Hazırlık | Aktivitede Harçanan Süre | Aktivite Gereksinimi İçin Süre | Workload | ||
| Course Hours | 14 | 2 | 28 | ||||
| Study Hours Out of Class | 14 | 4 | 56 | ||||
| Presentations / Seminar | 1 | 2 | 2 | ||||
| Homework Assignments | 1 | 2 | 2 | ||||
| Midterms | 1 | 1 | 1 | ||||
| Final | 1 | 1 | 1 | ||||
| Total Workload | 90 | ||||||