Istanbul Health and Technology University INFORMATION PACKAGE / COURSE CATALOGUE
| Pharmacy | |||||
| Bachelor | TR-NQF-HE: Level 6 | QF-EHEA: First Cycle | EQF-LLL: Level 6 | ||
Course General Introduction Information
| Course Code: | ECZ313 | ||||
| Course Name: | Pharmaceutical Chemistry I | ||||
| Course Semester: | Fall | ||||
| Course Credits: |
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| Language of instruction: | TR | ||||
| Course Requirement: | |||||
| Does the Course Require Work Experience?: | No | ||||
| Type of course: | Necessary | ||||
| Course Level: |
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| Mode of Delivery: | Face to face | ||||
| Course Coordinator : | Prof. Dr. SUMRU ÖZKIRIMLI | ||||
| Course Lecturer(s): |
Prof. Dr. SUMRU ÖZKIRIMLI |
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| Course Assistants: |
Course Purpose and Content
| Course Objectives: | The objective of this course is to teach the effects of physicochemical and structural properties on the activity; drug-receptor interactions, metabolism reactions and importance of metabolism reactions for drug development. |
| Course Content: | This course contains the knowledge of rational drug design; physicochemical properties, solubility of drugs, ionization of drugs; chemical bonds in drug-receptor interactions; stereochemistry-biological activity relationship; steric factors ; drug metabolism; bioizosterism; structure-activity relationship; prodrug designing and synthesis. |
Learning Outcomes
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The students who have succeeded in this course;
1) To be able to explain the distribution and ionization properties of drugs in the biological environment. 2) To be able to interpret the chemical bonds of drugs with targets 3) To be able to interpret the absorption processes of drugs. 4) Should be able to interpret the quantitative structure-activity relationship 5) Should have knowledge about the development methods of active compounds 6) To be able to interprete drug design 7) Should be able to know the chemical processes of drug metabolism 8) To be able to interpret the contribution of metabolism reactions to drug design in drug development processes. |
Course Flow Plan
| Week | Subject | Related Preparation |
| 1) | Importance of pharmaceutical (medicinal) chemistry in pharmacy education, Source of pharmaceutical raw materials. | |
| 2) | Pharmaceutical development, structure-activity relationship | |
| 3) | Bioisosterism, physicochemical factors affecting biologic activity | |
| 4) | Ionization constant (pKa), Henderson Hasselbach equation, inductive effect, resonance effect | |
| 5) | Hammet equation applications | |
| 6) | Evaluation of quantitative structure-activity relationship equation, QSAR equation evaluation | |
| 7) | Biological membranes, drug targets, receptors and types of receptors | |
| 8) | Midterm exam | |
| 9) | Chemical bonds in drug-target interactions | |
| 10) | Stereochemistry-biological activity relationship | |
| 11) | Receptors, enzymes and nucleic acids as drug targets | |
| 12) | Chemistry of drug metabolism | |
| 13) | Metabolism, Phase-I reactions | |
| 14) | Metabolism, Phase-II reactions | |
| 15) | Design of prodrugs, hard drugs and soft drugs |
Sources
| Course Notes / Textbooks: | |
| References: | Ders Kaynakları 1. Farmasötik ve Medisinal Kimya (I-II) Hülya Akgün/Ayla Balkan/A. Altan Bilgin/Ünsal Çalış/Sevim Dalkara/Dilek Demir Erol/Hakkı Erdoğan/Mevlüt Ertan/Nesrin Gökhan Kelekçi/Fügen Özkanlı/Erhan Palaska/Selma Saraç/Cihat Şafak/Rahime Şimşek/Birsen Tozkoparan .(2019) Hacettepe Üniversitesi Yayınları 2. Foye Medisinal Kimya Temel İlkeleri. Editörler : T L. Lemke, D A.Williams, S. W Zito , V F. Roche , Çev.Ed. Öztekin Algül, Kayhan Bolelli (2019) Ankara Nobel Tıp Kitapevi Yardımcı Kaynaklar 1. An Introduction to Medicinal Chemistry, G.L.Patrick, 6. Baskı (2017) Oxford University Press. 2. Foye's Principles of Medicinal Chemistry Victoria F. Roche ,S. William Zito Thomas Lemke, David A. Williams (2019) Walters Kluwer |
Course - Learning Outcome Relationship
| No Effect | 1 Lowest | 2 Medium | 3 Highest |
| Program Outcomes | Level of Contribution | |
| 1) | Access, evaluate and apply up-to-date scientific knowledge in the field of pharmacy | 5 |
| 2) | It conveys information to patients, health personnel and society on all matters related to drugs. | 5 |
| 3) | Has the necessary knowledge about the therapeutic effects, drug forms, pharmacokinetic properties, stability and incompatibilities of drug active substances and can use this information. | 5 |
| 4) | Recognizes, controls and standardizes quality assurance issues and processes of all pharmaceutical-related products. | 5 |
| 5) | Has knowledge and equipment about the administration and use of the drug to the patient, advises on rational and safe drug use, and supports pharmacovigilance practices. | 4 |
| 6) | Has knowledge about the production and production technologies of natural and synthetic pharmaceutical raw materials. | 5 |
| 7) | Have knowledge about the concepts related to the functioning, maintenance and pathology of biological systems that form the basis of human health. | 4 |
| 8) | Has sufficient knowledge and application skills on research, development and production of pharmaceutical and cosmetic products. | 5 |
| 9) | Plans and implements all subjects within the scope of pharmacy services in the hospital. | 4 |
| 10) | Has knowledge about licensing conditions, data protection, patent and pharmacoeconomics in pharmaceuticals. | 5 |
| 11) | She/He is administratively and technically equipped in every field where the pharmacy profession is responsible by law, and produces solutions to problems in line with scientific data / evidence. | 5 |
| 12) | Combines basic and applied sciences with pharmacy profession practices and uses them in the field of pharmacy. | 5 |
| 13) | Has sufficient knowledge and application skills on physical, chemical, biological and toxicological analyzes of pharmaceutical, biotechnological and radiopharmaceutical products. | 5 |
| 14) | Acts in accordance with ethical and legal principles in the field of pharmacy. | 5 |
| 15) | Has the necessary competencies to work with colleagues and other health professionals in terms of communicative, managerial and social skills. | 5 |
| 16) | Provides consultancy on medicinal plants, herbal supplements and food supplements. | 4 |
| 17) | Knows pharmaceutical care practices, understands and evaluates drug interactions. | 5 |
| 18) | Knows the risks associated with the use of drugs and other chemical substances and laboratory practice. | 5 |
Learning Activity and Teaching Methods
| Anlatım | |
| Course | |
| Okuma | |
| Problem Çözme | |
| Soru cevap/ Tartışma |
Measurement and Evaluation Methods and Criteria
| Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama) |
Assessment & Grading
| Semester Requirements | Number of Activities | Level of Contribution |
| Midterms | 1 | % 40 |
| Final | 1 | % 60 |
| total | % 100 | |
| PERCENTAGE OF SEMESTER WORK | % 40 | |
| PERCENTAGE OF FINAL WORK | % 60 | |
| total | % 100 | |
İş Yükü ve AKTS Kredisi Hesaplaması
| Activities | Number of Activities | Aktiviteye Hazırlık | Aktivitede Harçanan Süre | Aktivite Gereksinimi İçin Süre | Workload | ||
| Course Hours | 14 | 3 | 42 | ||||
| Study Hours Out of Class | 14 | 5 | 70 | ||||
| Presentations / Seminar | 1 | 1 | 1 | ||||
| Homework Assignments | 1 | 2 | 2 | ||||
| Quizzes | 1 | 1 | 1 | ||||
| Midterms | 1 | 1 | 1 | ||||
| Final | 1 | 1 | 1 | ||||
| Total Workload | 118 | ||||||