Molecular Biology and Genetics Preview
Bachelor	TR-NQF-HE: Level 6	QF-EHEA: First Cycle	EQF-LLL: Level 6

Course General Introduction Information

Course Code:

MBG408

Course Name:

Epigenetic

Course Semester:

Spring

Course Credits:

ECTS

Language of instruction:

Course Requirement:

Does the Course Require Work Experience?:

Type of course:

Area Ellective

Course Level:

Bachelor

TR-NQF-HE:6. Master`s Degree

QF-EHEA:First Cycle

EQF-LLL:6. Master`s Degree

Mode of Delivery:

Face to face

Course Coordinator :

Öğr.Gör. FATMA KÜBRA ATA

Course Lecturer(s):

Lecturer Fatma Kübra Ata

Course Assistants:

Course Purpose and Content

Course Objectives:

The aim of this course is to enable students to establish the link between molecular biology methods and epigenomic knowledge by providing students with an overview of the knowledge base on epigenetic mechanisms and their various roles in the regulation of developmental and physiological processes. On the other hand, it aims to gain a different perspective on various diseases with the acquired epigenetic knowledge.

Course Content:

Includes topics such as epigenetic mechanisms and epigenetic control

Learning Outcomes

The students who have succeeded in this course;
1) Be able to describe a wide range of molecular mechanisms involved in the epigenetic regulation of gene expression using examples from developmental and physiological processes,
2) Be able to explain, using a range of different examples, how epigenetic abnormalities underlie the pathobiology of some inherited and acquired diseases,
3) Gain an integrated understanding of how epigenetic processes shape phenotypes and alter disease risks
4) Be able to discuss the roles of the epigenome in the development and function of the nervous system throughout life and perceive how epigenetic processes play a role in healthy aging and the pathobiology of chronic disease

Course Flow Plan

Week	Subject	Related Preparation
1)	Introduction to Epigenetic Studies	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
2)	DNA Packaging and Chromatin Architecture	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
3)	Changing Chromatin Structure	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
4)	DNA Methylation, Post-Translational Modification of Histones	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
5)	Histone Modification Machines	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
6)	Locus-Specific Control of Histone-Modified Enzyme Action	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
7)	Epigenetic Control of Cell-Specific Gene Expression	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
8)	Midterm
9)	Epigenetic Control of the Mitotic Cell Cycle	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
10)	Epigenetic Basis of Gene Imprinting	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
11)	Epigenetic Control of Cellular Differentiation	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
12)	Reversibility of Epigenetic Modification Models	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
13)	Epigenetic Predisposition to Disease and Impression-Based Disorders	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
14)	Epigenetics of Memory, Neurodegeneration and Mental Health	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
15)	Epigenetics of Cancer	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
16)	Finals Week
17)	Finals Week

Sources

Course Notes / Textbooks:	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol
References:	Epigenetics, Lyle Armstrong, Epigenetics Handbook, Trygve Tollefsbol

Course - Learning Outcome Relationship

No Effect	1 Lowest	2 Medium	3 Highest

	Program Outcomes	Level of Contribution
1)	Having knowledge and understanding of Molecular Biology and Genetics subjects, established on competencies gained in previous education and supported by using course books containing latest information, application tools and other scientific literature.	2
2)	Students can integrate knowledge and skills from molecular biology and genetics courses and can acquire further knowledge according to their own interests.	2
3)	Students acquire practical skills in fundamental molecular biology and genetics techniques.	1
4)	Ability of proposing solutions in unexpected, complicated situations on applications of Molecular Biology and Genetics by claiming responsibility individually or as a part of a team.	1
5)	Competency in planning academic studies on Molecular Biology and Genetics and carrying out these studies individually or collectively.	1
6)	Students can develop ability to analyse and interpret experimental data obtained in a laboratory setting statistically.	1
7)	Sufficient foreign language knowledge for communication between colleagues and following literature on Molecular Biology and Genetics.
8)	Students can use computational technologies to analyse scientific data and for information retrieval.
9)	Being aware of the necessity of lifelong education, reaching information, following the advances in science and technology and constant struggle of renewing oneself.	2
10)	Evaluating natural and social events with an environmental point of view and ability of informing and leading the public opinion	3
11)	Students acquire professional knowledge and skills to fulfil requirements of their future employers.	2
12)	Having proper social, ethical and scientific values and the will to protect these values on studies about collection, evaluation, contemplation, publication and application of data regarding Molecular Biology and Genetics.
13)	Students can understand and evaluate advantages and limitations of technological platforms in life sciences including genomics, genetic engineering and biotechnology.	3
14)	Students would have consciousness on subjects such as the quality management, worker welfare and safety.

Learning Activity and Teaching Methods

Beyin fırtınası /Altı şapka
Course

Measurement and Evaluation Methods and Criteria

Yazılı Sınav (Açık uçlu sorular, çoktan seçmeli, doğru yanlış, eşleştirme, boşluk doldurma, sıralama)

Assessment & Grading

Semester Requirements	Number of Activities	Level of Contribution
Midterms	1	% 40
Final	1	% 60
total		% 100
PERCENTAGE OF SEMESTER WORK		% 40
PERCENTAGE OF FINAL WORK		% 60
total		% 100

İş Yükü ve AKTS Kredisi Hesaplaması

Activities	Number of Activities	Aktiviteye Hazırlık	Aktivitede Harçanan Süre	Aktivite Gereksinimi İçin Süre	Workload
Course Hours	17	2			34
Study Hours Out of Class	16	2			32
Midterms	1	24			24
Final	1	24			24
Total Workload					114